To help aging populations, classify organismal senescence
نویسندگان
چکیده
منابع مشابه
The thorny path linking cellular senescence to organismal aging.
Half a century is fast approaching since Hayflick and colleagues formally described the limited ability of normal human cells to proliferate in culture (Hayflick and Moorhead, 1961). This finding – that normal somatic cells, in contrast to cancer cells, cannot divide indefinitely – challenged the prevailing idea that cells from mortal multicellular organisms were intrinsically ‘immortal’ (Carre...
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Cellular senescence was first described by Hayflick and Moorhead in the 1960s as the irreversible arrest of cells following prolonged cultivation. Telomere shortening is the key mechanism driving replicative senescence in human fibroblasts. Later, pioneering work by Olivier Toussaint and others showed that stress plays a major role in the induction of senescence in vitro, a phenomenon known as ...
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Cellular senescence has long been used as a cellular model for understanding mechanisms underlying the ageing process. Compelling evidence obtained in recent years demonstrate that DNA damage is a common mediator for both replicative senescence, which is triggered by telomere shortening, and premature cellular senescence induced by various stressors such as oncogenic stress and oxidative stress...
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What is considered to be normal and what is considered to be diseased is strongly influenced by historical context (Moody, 2001/2002). Matters once considered to be diseases are no longer classified as such. For example, when black slaves ran away from plantations they were labeled to suffer from drapetomania and medical treatment was used to try to “cure” them (Reznek, 1987). Similarly, mastur...
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ژورنال
عنوان ژورنال: Science
سال: 2019
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.aay7319